Before starting her acting career, she worked as a model and gained fame after her first TV commercial in 1994. During her career, Meera has acted in over two hundred films including Urdu, Punjabi and Hindi. Meera has won the Best Actress award ten times and she has established herself as one of the leading contemporary actresses in the Pakistani film industry.Besides working in Lollywood films, Meera has also worked in Bollywood films. Meera has often been cited by the media for the most beautiful actress of Lollywood and won the Lux Style award for the most beautiful face of the year in 2007.
Meera plans to establish a social welfare organization that will provide shelter to homeless and needy women. The project will be named after her mother Shafqat Zara. A complex spread over an area of 16 acres (65,000 m2) of land will be constructed near Lahore comprising a school, hospital and home for the needy and homeless women. Meera's mother donated land for the project and Meera intends to complet the huge project herself.